Indoxyl sulfate potassium salt

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Indoxyl硫酸盐（钾盐）是人类芳基烃受体（AHR）的激动剂。芳基烃受体 (AhR) 最近已成为免疫炎症条件的病理生理调节剂，硫酸吲哚酚已被证明是 AhR 的配体。

Indoxyl sulfate (potassium salt) is an agonist for the human aryl hydrocarbon receptor (AHR). The aryl hydrocarbon receptor (AhR) has recently emerged as a pathophysiological regulator of immune-inflammatory conditions and Indoxyl sulfate has been shown to be a ligand for AhR. Indoxyl sulfate is also a metabolite of tryptophan derived from dietary protein. Tryptophan is metabolized by intestinal bacteria into indole which is absorbed into the blood and then further metabolized to indoxyl sulfate in the liver which is normally excreted in urine. In chronic kidney disease patients where renal function is compromised indoxyl sulfate can accumulate in serum as a uremic toxin inducing oxidative stress and accelerating progression of the disease. Indoxyl sulfate at 250 μM can induce the activation of NF-κB promoting the expression of both TGF-β1 and Smad3 expression in proximal tubular cells of rats which is associated with profibrotic activity.

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Potassium 3-indoxyl sulfate

Endocrinology/Hormones

AhR

AhR

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2642-37-7

251.3

C8H6KNO4S

>98% (HPLC)

DMSO:10 mM

[K+].[O-]S(=O)(=O)Oc1c[nH]c2ccccc12

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(-20℃)

With Ice Pack

≥ 2 years